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- Psychedelics for Phantom Limb Pain - Evaluating the effects of psilocybin vs Niacin on phantom limb pain and the potential neural mechanisms of this effect in a RCT with fMRI evaluations of functional connectivity changes between pre and post psilocybin.
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- Leveraging artificial intelligence and multimodal data to predict opioid addiction - Using electronic health record data, we are using state-of-the-art AI approaches from standard machine learning to large language models to predict risk of opioid addiction among diverse patient populations.
- Multi-omics analyses of opioid use disorder - We are exploring genomic and microbiome patterns of opioid use disorder. We use bioinformatics techniques to study whole genome sequencing, from GWAS to network propagation analyses to better understand genomic risk for addiction. Furthermore, we study patterns in the microbiome and metabolome that are associated with opioid use disorder.
- Predicting clinical deterioration among critically ill patients using artificial intelligence - Using large electronic health datasets, we use state-of-the-art AI approaches to predict, in real-time, various outcomes in the inpatient setting, including mortality, ARDS, myocardial ischemia, and stroke. We leverage a multimodal approach that integrates various types of clinical data to improve our ability to predict these outcomes.
- Improving preoperative optimization using artificial intelligence - In collaboration with the Anesthesia Preparedness Clinic, we are developing tools that can more efficiently screen and predict risk among surgical patients prior to their procedure. This includes using AI to process textual and structural data to make predictions and recommendations for anesthesia providers.
- Improving perioperative efficiency with artificial intelligence - Using UCSD electronic health record data, we use various machine learning and large language model approaches to better predict various key hospital efficiency metrics, including surgical case duration and hospital length of stay.
- Cryoneurolysis for painful diabetic neuropathy – a randomized sham-controlled clinical trial - We are currently running a randomized clinical trial assessing the efficacy of ultrasound-guided cryoneurolysis of the superficial peroneal nerve, sural nerve, and other nerves of the foot for painful diabetic neuropathy of the foot.
- Understanding the association of social determinants of health and surgical outcomes - Using large electronic health record datasets with social determinants of health data, we are running analyses on better understanding how an individual’s own social barriers may influence their outcomes after surgery and chronic pain diagnoses.
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- Improving Postamputation Functioning by Decreasing Phantom Limb Pain and Opioid Use with Perioperative Continuous Peripheral Nerve Blocks: A Multicenter RCT - The ultimate objective of the proposed research is to determine if a dense, week-long perioperative ambulatory continuous peripheral nerve block will improve post-amputation functioning
- Ultrasound-Guided Percutaneous Peripheral Nerve Stimulation: A Non-Pharmacologic Alternative for the Treatment of Postoperative Pain - The ultimate objective of the proposed research is to determine if ultrasound-guided, percutaneous peripheral nerve stimulation will provide postoperative analgesia for ambulatory shoulder and foot surgery
- Eliminating Post-Mastectomy Pain and Opioids with Percutaneous Cryoneurolysis: A Single-Administration, Non-Opioid, Non-Addictive, Multiple-Month Analgesic - The ultimate objective of this project is to determine if ultrasound-guided percutaneous cryoneurolysis is an effective treatment for postoperative pain following mastectomy
- Percutaneous Cryoneurolysis: A Single-Administration, Nonopioid, Nonaddictive, Multiple-Month Analgesic for Thoracic Trauma Free of Systemic Side Effects - The ultimate objective of this project is to determine if ultrasound-guided percutaneous cryoneurolysis is an effective treatment for postoperative pain following mastectomy
- A Randomized, Single-Blinded, Sham-Controlled Study Evaluating the Efficacy and Safety of RELAY, a Device Enabling Both Local Anesthetic Delivery and Neuromodulation for Postoperative Analgesia, in Participants Having Shoulder or Foot Surgery Following a Single Arm Training Run-In - This is a single-center, sham-controlled study to investigate the efficacy and safety of RELAY (Gate Science, Boston, MA), a device that enables the delivery of both local anesthetic and neuromodulation (peripheral nerve stimulation) to treat postoperative pai
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The Lerman Lab, led by Dr. Imanuel Lerman, is at the cutting edge of bioelectronic medicine research, focusing on innovative approaches to detect and treat inflammation through advanced technologies. The lab is pioneering the development of closed-loop systems that integrate focused ultrasound, autonomic neurography (ANG), and artificial intelligence to monitor and manage inflammatory conditions inflammatory mediated chronic pain. With a commitment to non-invasive therapies, the Lerman Lab is dedicated to improving clinical outcomes, leveraging a collaborative approach with industry partners and integrating state-of-the-art biosensors and cloud platforms into their research with the aim to improve patients lives and health-span. -
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- Dr. Angela Meier is a board-certified anesthesiologist and intensivist who bridges clinical expertise with laboratory research.
- The Meier Lab investigates how anesthetics, sedatives, and novel immune-modulating nanoparticles influence immune responses, both in vitro and in the context of infections such as severe pneumonia and sepsis
- Dr. Meier’s clinical research interests are deeply integrated with her medical practice, encompassing mechanical ventilation, ECMO, sepsis, leadership in cardiopulmonary resuscitation and critical care for patients with lung and heart transplantation
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- Principal Investigator, Online Physical Therapy Videos, UC San Diego, 2020-Present - Created a series of online physical therapy videos to treat the most commonly encountered painful conditions in EDs and outpatient clinics. Studying patient and provider satisfaction.
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Principal Investigator, Teachability of the Erector Spinae, UC San Diego, 2020-Present -Assessment of the use of QR codes for the use of home instructional discharge videos
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Principal Investigator, Ultrasound Guided Nerve Block Curriculum, UC San Diego 2025 - Created a nerve block curriculum for emergency medicine residents and implemented QR codes in the ED for point-of-care reference.
- Principal Investigator, Improving ED Migraine Management, UC San Diego 2025 - Principal Investigator on a project to improve emergency department migraine management using novel CGRP analogs by developing an EPIC order set for standardized, evidence-based treatment.
- Sub-Investigator, phase 1 clinical trial 2024-2025, 10% funding, 2025-2026 - NIH/NIAAA R44 AA024905. $1,600,000 2024-2025 Nezavist, A Novel Molecule for Treatment of Alcohol Use Disorder
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- EN21 -Phase 2 RCT studying novel medication for painful diabetic peripheral neuropathy
- RELIEV-CM2- Pivotal RCT studying novel implantable device for refractory chronic migraine
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- TMS Research for Phantom Limb Pain - Investigate novel transcranial magnetic stimulation (TMS) sequences to modulate cortical reorganization and alleviate phantom limb pain in amputees.
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Implantable Neuromodulation Devices for Low Back Pain - Developing innovative implantable neuromodulation device aimed at treating facetogenic low back pain through targeted nerve modulation.
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Medical Devices for Anesthesiology and Chronic Pain Management - Conducting research into various new medical devices designed to improve anesthesiology and chronic pain management.
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- A Novel Therapeutic to Ameliorate Chronic Pain and Reduce Opiate Use - NIH funded (NIDA UG3 DA047680)) phase IA study in healthy volunteers to determine safety, tolerability and drug pharmacokinetics of a new therapeutic for chronic pain
- Nezavist, A Novel Molecule for Treatment of Alcohol Use Disorder - NIH funded ( NIAAA R44 AA024905) phase IA study in healthy volunteers to determine safety, tolerability and drug pharmacokinetics of a new therapeutic for alcohol use disorder
- An interventional, Phase III, double-blind, randomized, controlled, parallel-group, multi-site, clinical trial evaluating the efficacy and safety of Qutenza in subjects with post-surgical neuropathy. -Industry sponsored Phase III study to determine the efficacy and safety of high dose topical capsaicin for chronic postsurgical neuropathic pain
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