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Department of Anesthesiology Department of Anesthesiology
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Therapeutic Nanocarriers

nanocarriers

Nanoparticle Design

Poor ability of drugs to cross intact neurovascular barriers limits their therapeutic efficacy in neurological and mental health disorders. Nanoparticles can be designed as trackable, intact neurovascular barrier-crossing drug and gene carriers.

Our Research

These unique properties of nanoparticles are revolutionizing the field of personalized medicine (reviewed in 1). We work to understand the interface of nanoparticles with cells of the nervous and immune systems in order to develop potent and safe nanoparticles for therapeutic, diagnostic and theranostic platforms (2-4). In follow-up to our Controlled Release Society Jorge Heller Outstanding Paper research in designing silicacoated magnetic nanobowls (5), we are working to develop new generation nanodevices (bowls and nano-golf balls (6), as shown in the micrograph (courtesy of Ratnesh Lal at UC San Diego).

Representative Papers

  1. Shubayev VI, Pisanic TR II, Jin S: Magnetic nanoparticles for theragnostics, Adv. Drug. Deliv. Rev., 61 (6): 467-77, 2009.
  2. Pisanic TR II, Blackwell JD, Shubayev VI, Finones RR, Jin S: Nanotoxicity of iron oxide nanoparticle internalization in growing neurons, Biomaterials, 28 (16): 2572-81, 2007.
  3. Kim Y, Kong S, Chen LH, Pisanic TR II, Jin S, Shubayev VI: In vivo nanoneurotoxicity screening based on oxidative stress and neuroinflammation paradigms, Nanomedicine, 9 (7): 1057-66, 2013.
  4. Pisanic T, Jin S, Shubayev VI: Iron Oxide Magnetic Nanoparticle Nanotoxicity: Incidence and Mechanisms. In Nanotoxicity: From Health Risk to In Vitro and In Vivo Models. (Sahu SC, Casciano DA, editors), J. Wiley & Sons Ltd (20): 397-425, 2009.
  5. Kong S, Lee J, Ramachandran S, Eliceiri B, Shubayev VI, Lal R, Jin S: Magnetic targeting of nanoparticles across the intact blood-brain barrier, J. Control. Release, 164 (1): 49-57, 2012.
  6. Mo AH, Zhang C, Landon P, Janetanakit W, Hwang M, Santacruz Gomez K, Colburn D, Dossou S, Lu T, Cao Y, Sant V, Sud P, Akkiraju S, Shubayev VI, Glinsky G, Lal R: Dualfunctionalized theranostic nanocarriers, ACS Appl. Mater. Interfaces, 8 (23): 14740-46, 2016.