Research

William Wilson, MD

E-mail : wwilson@ucsd.edu

My research interests center primarily upon pulmonary physiology and airway management.  I also have a strong additional interest in neuroprotection and monitoring. My focus on these areas of research stems from my clinical experience, having cared for patients with injuries involving these areas for over a decade. Regarding pulmonary physiology, I am the lead author of an often-cited article chronicling the effect of Inhaled nitric oxide (INO) during one-lung ventilation (below). I was the first anesthesiologist in San Diego to use this gas on patients, and one of the firsts in the USA. Additionally, I am the principal investigator on an operating room study investigating the parameters of preoxygenation that effect the time until desaturation following apnea. Regarding emergency airway management, I am particularly interested in techniques employed for facilitating intubation and ET tube verification in emergency and critical care situations. We completed a study on the Incidence of Difficult Direct Laryngoscopy in Trauma Patients.  Our principle findings were that difficult laryngoscopy is 5 times more common in trauma patients than elective patients <0.05), and can be predicted on the basis of preoperative airway evaluation, anatomic site of injury (max-face trauma associated with increased difficulty), and sex (males more likely to have a difficult airway than females). My interest in neuroprotection stems from my long time participation in the care of neurosurgical patients. I am currently the Principal investigator on a study looking at the effect of immune modulating diets in severely traumatized patients (with and with out head injury). My clinical responsibilities are divided between critical care medicine and cardiothoracic anesthesia. My investigational interests include: emergency airway management, trauma resuscitation, thoracic anesthesia, effects of inhaled nitric oxide on pulmonary vascular tone and oxygenation, neuroprotection, and ethics in medicine. Current projects include: 1) Dexmedetomidine associated alterations in CMRO2 and ventilatory control in normal and head injured patients; 2) Fiberoptic bronchoscopic characterization of airway in patients who do and do not tolerate extubation.

References (Selected From 8 Publications)

Manecke GR Jr, Parimucha M, Stratmann G, Wilson WC, Roth DM, Auger WR, Kerr KM, Jamieson SW, Kapelanski DP, Mitchell MM. Deep hypothermic circulatory arrest and the femoral-to-radial arterial pressure gradient. J Cardiothorac Vasc Anesth ;18:175-9. 2004.

Wilson WC (Editor); Monitoring During Critical Events. Anesthesiology Clinics of North America. Published by W.B. Saunders Co. 2001.

Wilson WC, Kapelanski D, Benumof JL, John W. Newhart JW, Johnson FW, Channick RN: Inhaled nitric oxide (40 ppm) during one-lung ventilation, in the lateral decubitus position, does not decrease pulmonary vascular resistance or improve oxygenation in normal patients. J. Cardiothoracic and Vasco Anesthesia 11(2):172-176, 1997.

Wilson WC, Patel N, Hoyt DB, Murphy MT: Peri operative Anesthetic Management of Patients with Abdominal Trauma. In, Grande CM, and Smith CE (eds): Anesthesiology Clinics of North America. Philadelphia, PA, W.B. Saunders. 17(1): 211-236, 1999.