Research

David M. Roth, MD, PhD

E-mail : droth@ucsd.edu

My laboratory focuses on basic mechanisms of cell survival and growth as they relate to myocardial ischemia/reperfusion injury, heart failure and the aging heart. Specifically, we study compartmentation of signaling in subcellular compartments such as caveolae which we have found to be key regulatory elements in cellular and organ function. Over the years we have developed a number of tools that include transgenic mice, targeted vectors, and biochemical, microscopy and echocardiography techniques to study the role of caveolae in heart disease. Recently, we have applied such technology to the study of cardiovascular disease, neurological disorders, pain, cancer and the aging heart and brain. Our findings indicate that there is an interaction of caveolin proteins with mitochondria that may be key to regulating a more global response to stress and provide a molecular switch for cell survival and death. Clinical research addressing novel relationships of vasopressors in patients with right heart failure also are ongoing. Our laboratory employs state of the art molecular, biochemical, cellular, organ based, and in vivo techniques. We have strong collaborative relationships with other departments, divisions and cores at UCSD including, Medicine, Cardiology, Cardiothoracic Surgery, Bioengineering, Pharmacology and Cellular and Molecular Medicine. I stress a collaborative and engaging mentorship of my trainees that stresses development of non-technical science skills. The unique blend of cutting edge techniques and rigorous scientific development will provide a very robust environment for the development of new trainees.    See website: http://rppresearchgroups.ucsd.edu.

References  (Selected From 104 Publications)

Sastri M, Haushalter KJ, Panneerselvam M, Chang P, Fridolfsson H, Finley JC, Ng D, Schilling JM, Miyanohara A, Day ME, Hakozaki H, Petrosyan S, Koller A, King CC, Darshi M, Blumenthal DK, Ali SS, Roth DM, Patel HH, Taylor SS. A kinase interacting protein (AKIP1) is a key regulator of cardiac stress.  Proc Natl Acad Sci U S A. 2013 Jan 29; 110(5): E387-96.

Gao MH, Lai NC, Miyanohara A, Schilling JM, Suarez J, Tang T, Guo T, Tang R, Parikh J, Giamouridis D, Dillmann WH, Patel HH, Roth DM, Dalton ND, Hammond HK. Intravenous adeno-associated virus serotype 8 encoding urocortin-2 provides sustained augmentation of left ventricular function in mice. Hum Gene Ther. 24(9): 777-85, 2013.

Okada H, Lai NC, Kawaraguchi Y, Liao P, Copps J, Sugano Y, Okada-maeda S, Banerjee I, Schilling JM, Gingras AR, Asfaw EK, Suarez J, Kand SM, Perkins GA, Au CG, Israeli-Rosenberg S, Manso AM, Liu Z, Milner DJ, Kaufman SJ, Patel HH, Roth DM, Hammond HK, Taylor SS, Dillmann WH, Goldhaber JI, Ross RS. Integrins protect cardiomyocytes from ischemia/reperfusion injury. J Clin Invest 123(10): 4294-308, 2013.

Horikawa YT, Tsutsumi YM, Patel HH, Roth DM. Signaling Epicenters: The role of caveolae and caveolins in volatile anesthetic induced cardiac protection. Curr Pharm Des February 3, 2014. [Epub ahead of print.]

Nguyen L, Banks D, Manecke G, Shurter J, Schilling JM, Patel HH, Madani MM, Roth DM.  Plasma Vasopressin Levels in Patients with Right-Sided Heart Dysfunction and Chronic Thromboembolic Pulmonary Hypertension (CTEPH). J Cardiothorac Vasc Anesth. April 15, 2014 [Epub ahead of print.]

Biography:

Lock Haven State College, Lock Haven, PA

B.S.

1980

Biology/Chemistry

Thomas Jefferson University, Philadelphia, PA

Ph.D.

1984

Physiology

University of CA, San Diego School of Medicine

M.D.

1993

Medicine

University of CA, San Diego School of Medicine

Residency

1997

Anesthesiology

1983-present     Member ,American Physiological Society

1994-present      Member, American Society of Anesthesiologists; California Society of Anesthesiologists

1997-present      Member, Society for Cardiovascular Anesthesiologists

2009-present      Member, American Society for Pharmacology and Experimental Therapeutics

2000-present      Member, American Heart Association, Basic Science Council

2005-2007          Invited Grant Reviewer, National Institutes of Health: National Heart, Lung and Blood Institute

2007-2011          Regular Member, Myocardial Ischemia and Metabolism (MIM) Study Section: National Institutes of Health: National Heart, Lung and Blood Institute

2012                   NIH Cardiovascular Sciences Special Emphasis Panel (SEP) Invited Reviewer

2006-2012          Associate Editorial Board Member for Anesthesiology

2014-  Editor for Anesthesiology