My current and future research interests aim to:
- Utilize molecular, cellular, and whole animal approaches to understand physiology/pathophysiology in different organ systems
- My laboratory utilizes cellular models, such as isolated adult rat and mouse cardiac myocytes and neurons, to understand the cellular and sub-cellular consequences of various pathophysiologies
- These isolated cell systems are more amenable to biochemical and molecular interventions to understand in more sophisticated detail the mechanisms that are at play in disease and can be exploited to elicit protective responses
- I use translational models (i.e., transgenic and knockout mice, an intact and ex vivo rat model of ischemia-reperfusion injury, and in vivo pharmacologic studies) to bridge the in vitro biochemical and molecular outcomes to a better understanding of whole organ and animal function
- I am interested in how cellular signaling is organized and coordinated in cells and how this is impacted
by various disease processes
- My laboratory is specifically interested in how membrane microdomains, such as caveolae, interact and communicate with intracellular organelles, such as mitochondria, to impact cell, organ, and animal physiology
- I hope that this multi level approach to the study of disease will lead to fundamental discoveries related to heart disease, stroke, diabetes, cancer and aging
Patel HH, Murray F, Insel PA. Caveolae as organizers of pharmacologically relevant signal transduction molecules.
Annu Rev Pharmacol Toxicol 48:359-391, 2008
Head BP, Patel HH, Tsutsumi YM, Hu Y, Mejia T, Mora RC, Insel PA, Roth DM, Drummond JC, Patel PM. Caveolin-1
expression is essential for N-methyl-D-aspartate receptor-mediated Src and extracellular signal-regulated kinase
1/2 activation and protection of primary neurons from ischemic cell death Faseb J. 22:828-840, 2008.
Patel HH, Zhang S, Murray F, Suda RY, Head BP, Yokayama U, Swaney JS, Niesman IR, Schermuly RT, Pullamsetti SS,
Thistiethwaite PA, Miyanohara A, Farquhar MG, Yuan JX, Insel PA. Increased smooth muscle cell expression of
caveolin-1 and caveolae contribute to the pathophysiology of idiopathic pulmonary arterial hypertension. Faseb J.
Patel HH, Tutsumi YM, Head BP, Niesman IR, Jennings M, Horikawa Y, Huang D, Moreno AL, Patel PM, Insel PA,
Roth DM. Mechanisms of cardiac protection from ischemia/reperfusion injury: a role for caveolae and caveolin-1.
Faseb J. 21:1565-1574, 2007.
Patel HH, Head BP, Petersen HN, Niesman IR, Huang D, Gross GJ, Insel PA, Roth DM. Protection of
adult rat cardiac myocytes from ischemic cell death: role of caveolar microdomains and delta-opioid receptors Am J
Physiol Heart Circ Physiol. 291:H344-350, 2006.