Research

R. Carter W. Jones III, M.D. Ph.D.

Lab description

Chronic pain is a common and difficult to treat medical problem.  My research interests are to identify the causes of and potential treatments for chronic pain.  This includes basic science experiments focusing on understanding the mechanisms of visceral pain, discovering potential biomarkers for the development and treatment of pain, and developing novel animal models for pain conditions that are poorly understood.  These studies complement my clinical research that is designed to develop a deeper understanding of the pathogenesis of chronic pain conditions like complex regional pain syndrome, inflammatory bowel disease, fibromyalgia, and to test novel therapeutic strategies for the treatment of chronic pain, including intrathecal drug delivery as well as non-invasive techniques.

 

Representative publications

Jones III RCW and Backonja MM (2013) Review of Neuropathic Pain Screening and Assessment Tools, Current Pain and Headache Reports, Vol. 17:363.

Jones III RCW, Moeller-Bertram T, Wallace MS (2012) Safety and Efficacy of Intrathecal Drug Delivery for Pain. Pain Management, Vol. 2:55-61.

Docherty MJ, Jones III RCW, Wallace MS (2011) Managing Pain in Inflammatory Bowel Syndrome.  Gastroenterology and Hepatology. Vol. 7:592-601.

Jones III RCW, Otsuka E, Jensen C, Price M, Gebhart GF (2007) Short-term sensitization of colon mechanoreceptors is associated with long-term colon hypersensitivity in the mouse, Gastroenterology, Vol. 133: 184.

Gebhart GF, Bielefeldt K, Dang K, Xu L, Jones III RCW, Lamb K. “Visceral Pain and Visceral Hypersensitivity” in Proceedings of the 11th World Congress on Pain, eds. H Flor et al., IASP Press: Seattle, 2006.

Jones III RCW, Xu L, Gebhart GF (2005) The mechanosensitivity of mouse colon afferent fibers and their sensitization by inflammatory mediators require TRPV1 and ASIC3, Journal of Neuroscience, Vol. 25: 10981-10989.

Brierley SM, Jones III RCW, Gebhart GF, Blackshaw LA (2004) Splanchnic and pelvic mechanosensory afferents signal different qualities of colonic stimuli in mice, Gastroenterology, Vol. 127: 166-179.

Brief Biography

B.A., Biology, Williams College, Williamstown, MA - 1997

M.D., Ph.D., Pharmacology, University of Iowa, Iowa City, IA - 2006

Internship, Internal Medicine, University of Colorado Health Sciences Center, Denver, CO - 2007

Residency, Anesthesiology, University of California San Francisco, San Francisco, CA - 2010

Fellowship, Pain Medicine, University of California San Diego, San Diego, CA – 2011

Assistant Professor, Department of Anesthesiology, UC San Diego, San Diego, CA – 2011-present